I am interested in the structure and dynamics of biological macromolecules at different scales, starting from the electron density and electrostatic potential distributions of the single atoms, up to the large macromolecular complexes. I find the systems containing RNA and proteins particularly interesting as they are built from repetitive building blocks but at the same time serve many functions.

A variety of computational and experimental methods helps me to get an insight into those molecules. I am an expert in molecular dynamics simulations with enhanced sampling, also with flexible fitting to the Cryo-EM density maps. I performed many calculations of electrostatic interaction energies using advanced aspherical models of electron density and calculations of the electrostatic potential density maps. I have also experience in X-ray crystallography of small molecules, circular dichroism, UV-VIS spectroscopy with measuring the temperatures of melting and isothermal titration calorimetry.